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Molecular Diagnosis: Pathogen Detection & Identification
Molzym offers universal PCR or Real-Time PCR-based systems for the culture-independant diagnosis of any pathogen present in a clinical specimen. In case of positive results from the detection assay, amplicons are subjected to sequence analysis to identify the infectious agent. Primers are included in all kits for sequencing reactions. Instead of days needed by culturing, pathogens are detected within a working day and identified over night.
Products: SepsiTest™ CE-IVD - whole blood; UMD™ Liquid CE-IVD - body liquids; UMD™ Swab CE-IVD - wound swabs; UMD™ Tissue CE-IVD - biopsies; UMD™ Universal CE-IVD - broad-range of clinical material
Automated Molecular Diagnosis
The latest development is our complete system, comprising of automated pathogen DNA extraction from whole blood combined with PCR/Real-Time PCR universal detection of bacteria and fungi and sequence-based identification. This product significantly reduces hands-on time thereby aiding in the rapid diagnosis of etiological agents of sepsis.
Products: SelectNA™ - instrument for the automated DNA extraction; SepsiTest™ SelectNA CE-IVD - kit for the extraction and PCR/Real-Time PCR analysis of pathogen DNA from whole blood
Microbe Differentiation
Molzym offers a PCR/Real-Time PCR assay that detects sequences from Gram-positive organisms including staphylococci, streptococci and enterococci. The assay ideally complements the universal assays, SepsiTest™, SepsiTest™ SelectNA and UMD™. For sequence analysis of positive samples a free online Blast tool, SepsiTest™-BLAST, is available. The tool relies on edited sequences from more than 7,000 cultured bacteria, yeasts and Aspergillus species.
Products: Mastermix Assay GP (research use only) - assay for Gram-positive pathogens; SepsiTest™-BLAST - tool for sequence identification of microorganisms
Sample Storage
Containers are available for the collection and deep freeze-storage of liquid clinical samples for subsequent molecular analysis. The containers are DNA-free and hence prevent consumable-borne false-positive results. The thus stored samples are ideal for molecular analysis employing PCR-based assays, including SepsiTest™, SepsiTest™ SelectNA and UMD™.
Products: UMD™ Tubes - storage of whole blood and other primary body liquids
Technology & References
In this section the underlying technology of the SepsiTest™, SepsiTest™ SelectNA and UMD™ kits is described. Further, experience with the kits in several clinical evaluations is reported and reference to published data is given.