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Molzym Inside
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Thank You for Visiting Us at ECCMID

15 May 2018

The Molzym-Team was delighted to participate and exhibit at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) that took place in Madrid, Spain, from 21st to 24th of April 2018. Here we want to share some impressions and highlights of this year’s ECCMID with you.

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NGS
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Standardised Method for Infection Diagnosis with NGS

08 May 2018

In a poster presentation at this year’s ECCMID congress, Edelmann et al. [1] compared 4 DNA extraction kits and the influence of human DNA removal for use in microbiome analysis. Additionally, two master mixes were tested for bacterial DNA contamination. An efficient workflow towards a standardised use of NGS in infection diagnosis was proposed.

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Automation
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Automated Microbial DNA Enrichment in Clinical Routine

30 April 2018

Micro-Dx™ combines automated pathogen enrichment and DNA extraction with broad-range PCR and sequencing ID of species. A multi-centre analysis of 409 routine samples of tissues, fluids and swabs indicated acceptable diagnostic performance in comparison to other molecular tests and culture. Additional pathogens could be identified by Micro-Dx™.

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NGS
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Comparison of Microbial DNA Enrichment Tools for WGS

27 April 2018

In most clinical samples, human DNA outnumbers the amount of pathogen DNA. Therefore, pathogen analysis with metagenomic whole genome sequencing (MWGS) is often limited by unspecific primer binding to human sequences. Read a comparison study of two commercial kits with respect to their enrichment of microbial DNA and effect on MWGS.

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Molzym Inside
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Molzym Exhibits at ECCMID Congress in Madrid

17 April 2018
The European Congress on Clinical Microbiology and Infectious Diseases is an important event that attracts specialists in the fields globally. Molzym will be exhibiting their innovative products for rapid culture-independent molecular pathogen diagnosis focussing on unique automation of microbial DNA enrichment from diverse clinical specimens.
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Newsletter
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Special Edition on the Occasion of ECCMID 2018

17 April 2018
In this special newsletter we highlight some noteworthy presentations on this year's ECCMID. Don't miss out the new developments in 16S metagenomics, diagnostic approaches in bacterial bloodstream infections and in innovations in molecular pathogen detection. Stop by our booth #159 and explore our portfolio of products.

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Automation
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Automated Enrichment of Pathogen DNA from Heart Valves

16 April 2018
The SelectNA™plus robot with DNA-free Micro-Dx™ kit reagents (SNP) enriches pathogens and isolates microbial DNA from specimens automatically. In this post, a 16S/18S PCR and sequencing analysis  of heart valves and other biopsies from 52 infectious endocarditis patients is discussed. SNP found substantially more relevant pathogens than culture.
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NGS
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NGS Analysis of Pathogens in Broncho-Alveolar-Lavage

12 April 2018
Whole-metagenome sequencing generates vast non-target reads at a high host to bacterial DNA relation in some clinical samples. The removal of host DNA increases the reads and coverage of bacterial sequences. Read a summary of an exemplary publication showing the benefits of host DNA removal and how it can positively affect your NGS results.

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Molecular Diagnostics
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Culture-Independent Molecular Diagnosis in Routine

11 April 2018
SepsiTest™-UMD uses rDNA PCR and sequencing analysis to identify pathogenic bacteria and fungi from uncultured clinical material. Bacterial pathogens from 160 genera within 8 phyla have been identified in studies. SepsiTest™-UMD reflects an unbiased approach of culture diagnosis but is faster and more comprehensive by detecting non-growing pathogens.
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Newsletter
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Diversity of Pathogens in 16S rDNA Routine Diagnosis

Vol 3/2018
Two case reports address the added value of broad-range 16S rDNA PCR in pathogen diagnosis. In case 1, standard methods were negative while PCR identified a pathogen. In case 2, an unusual bacterial pathogen was identified by PCR. Read also an application note on the benefits of culture-independent diagnosis of pathogens in daily routine.
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Pathogen DNA Isolation
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MolYsis™ Host DNA Removal – Effect on Pathogen Analysis

09 April 2018
In clinical specimens with low microbial load, host DNA at large excess negatively influences amplification of target pathogen DNA. This contribution guides through Molzym’s MolYsis™ technology of host DNA removal in front of microbial DNA extraction systems. The positive effect of host DNA removal on molecular analysis is discussed.

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Molzym Inside
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Micro-Dx™ Molecular Pathogen Test Gets CE IVD Mark

09 April 2018
Molzym introduces its latest development in automation. Micro-Dx™ comprises automated human DNA removal and pathogen DNA enrichment together with broad-range 16S/18S rDNA amplification and sequencing analysis. The system went through clinical studies showing its benefit for culture-independent pathogen diagnosis in daily routine.
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Newsletter
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Whole Genome Sequencing in Routine Infection Diagnosis

Vol 2/2018
In this newsletter, we focus on the application of whole genome sequencing for pathogen detection in clinical routine and the challenges coming along with it. Three featured publications discuss, among others, the impact of DNA extraction, the problem of microbial contaminations of reagents and the need for improved resolution and standardisation.
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DNA-free Reagents
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DNA-Free Hot MolTaq 16S/18S: Low Load Microbial DNA Detection

09 April 2018
One of the major challenges in molecular microbe detection are false-positive results due to DNA contaminations of amplification reagents. Molzym’s new proprietary Hot MolTaq 16S/18S is a high quality, DNA-free Taq DNA polymerase ideally suited for the sensitive PCR analysis of microbial target DNA even at very low concentrations. Find out the benefits.
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Newsletter
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Micro-Dx™ Received CE IVD Marking

Vol 1/2018
Our latest development, Micro-Dx™, received CE mark for in vitro diagnostics. Micro-Dx™ comprises automated pathogen DNA enrichment  from clinical material on the SelectNA™plus robot together with 16S/18S rDNA amplification and sequencing analysis. Results of multi-sites evaluations by routine labs are summarised in an application note.
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